Wavetek 131A Manual do Utilizador descarregar pdf (Página 7)

1000 μV

1 sec

1000 μV

1 sec

1000 μV

1 sec

12 3

1000 μV

1 sec

1000 μV

1 sec

1000 μV

1 sec

1000 μV

1 sec

1000 μV

1 sec

Number of seizures/hour

Mice showing seizures

Postnatal a

(

)

0,5

1,5

2,5

P9 P10 P11 P12 P13 P14 P15

20%

40%

60%

80%

100

150

200

250

Seizure duration (sec)

Postnatal a

(

)

P9 P10 P11 P12 P13 P14 P15

Figure 4 Simultaneous video–EEG recordings of the cortex and the hippocampus in homozygous LGI1

/

mice. (A) Two electrodes

located in the dorsal hippocampus (Hp) and one in the adjacent cortex (Cx) record an electroclinical seizure. Behavioural modiﬁcations are

correlated with EEG event: 1 = immobility; 2 = myoclonic jerks; 3 = agitation and wild running; 4 = four-limb hypertonia. In the lower panel,

an expanded EEG trace shows initial spike discharges of increasing amplitude, which begin earlier in the hippocampus than in the cortex

and then pseudo-periodic slow potentials with an imposed polyspike activity. (B) Brief electrical seizure, with no clinical correlate. In this

example, which was limited to the hippocampus, polyspikes, resembling interictal activity followed a low voltage fast activity of duration

2 s (see the lower panel for magniﬁcation). (C) Interictal activity, restricted to the hippocampus, showing high-amplitude spikes and

polyspikes. This activity is increased after electroclinical seizures. (D) Postictal delta slow waves and depression of the activity at the end of

an electroclinical seizure. (E) Physiological theta rhythm, with maximum amplitude in the hippocampus. (F and G) EEG analysis of

52 spontaneous electroclinical seizures recorded in LGI1

/

mice (n = 6). (F) Percentage of mice showing seizures from postnatal

days 9–15 during recordings (curve; axis on the right) and seizure frequency (histogram; axis on the left). (G) Seizure duration.

Means and SEM are indicated.

LGI1 knockout mice Brain 2010: 133; 2749–2762 | 2755

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